![]() ![]() This PEC biosensor generated a strong photocurrent with low blank (27.6 nA) and was sensitive to α-Syn oligomer. The output FT was used for the cycle II catalytic hairpin assembly onto the electrode which was modified with AuNPs/GDY and triple-stranded DNA (TsDNA) thereby, plenty of PEC nanoprobes which are composed of probe DNA and the signal indicator are captured, and the photocurrent response is produced correspondingly. In the presence of the α-Syn oligomer, the target triggered cycle I strand displacement amplification and achieved the conversion of the α-Syn oligomer to a massive output of false-target DNA (FT). The signal indicator, dopamine/4-mercaptophenyl boronic acid/WSe 2 (DA/MBA/WSe 2), was generated with the recognition of boron–diol. Due to the synergistic effect of AuNPs/GDY and WSe 2, this detection strategy provides a high signal-to-noise ratio and good performance. The synergy effect between the WSe 2 nanoflower and graphdiyne (GDY) can reduce the photoinduced electron–hole recombination and expedite the spatial charge separation. A tungsten selenide (WSe 2) nanoflower was first produced with a one-pot solvothermal method and employed as a signal amplification element and the modified substrate of the nanoprobe. We developed a method for photoelectrochemical (PEC) sensing based on a AuNPs/graphdiyne, as a low background signal composite material, modified electrode coupled with a nanoprobe (probe DNA/DA/MBA/WSe 2) for sensitive α-synuclein (α-Syn) detection. ![]()
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